High Precision DNA Modification Analysis ofHCG9in Major Psychosis
نویسندگان
چکیده
منابع مشابه
High Precision DNA Modification Analysis of HCG9 in Major Psychosis
New epigenetic technologies may uncover etiopathogenic mechanisms of major psychosis. In this study, we applied padlock probe-based ultra-deep bisulfite sequencing for fine mapping of modified cytosines of the HLA complex group 9 (nonprotein coding) gene in the postmortem brains of individuals affected with schizophrenia or bipolar disorder and unaffected controls. Significant differences betwe...
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Epigenetic misregulation is consistent with various non-Mendelian features of schizophrenia and bipolar disorder. To date, however, few studies have investigated the role of DNA methylation in major psychosis, and none have taken a genome-wide epigenomic approach. In this study we used CpG-island microarrays to identify DNA-methylation changes in the frontal cortex and germline associated with ...
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ژورنال
عنوان ژورنال: Schizophrenia Bulletin
سال: 2015
ISSN: 0586-7614,1745-1701
DOI: 10.1093/schbul/sbv079